EC Number   |
Natural Substrates |
|---|
   2.7.11.16 | ATP + a G protein-coupled receptor |
the GRKs are important in the cardiovascular system, the major G protein-coupled receptor regulatory pathway involves phosphorylation of activated receptors by GRKs, followed by binding of arrestin proteins, which prevent receptors from activating downstream heterotrimeric G protein pathways while allowing activation of arrestin-dependent signaling pathways, general mechanisms of GRK-arrestin regulation, overview, physiological functions and potential pathophysiological roles of GRKs and arrestins in human disorders, overview |
| 2.7.11.16 | ATP + alpha-synuclein |
GRK5 phosphorylates Ser-129 of alpha-synuclein at the plasma membrane and induces translocation of phosphorylated alpha-synuclein to the perikaryal area, GRK5 promotes alpha-linolenic acid-induced oligomerization of alpha-synuclein, alpha-synuclein phosphorylation by GRK5 plays a crucial role in the pathogenesis of sporadic Parkinson's disease, sPD |
| 2.7.11.16 | ATP + ATP + G protein-coupled receptor |
- |
| 2.7.11.16 | ATP + beta-adrenergic receptor |
desensitization of the receptor by GRK4, GRK5, and GRK6 |
| 2.7.11.16 | ATP + BLT1 receptor |
GRK6, ablation of GRK6 leads to augmented signaling by leukotriene B4 acting through the BLT1 receptor |
| 2.7.11.16 | ATP + central M2 muscarinic receptor |
desensitization of the receptor by GRK5, GRK5 regulates pulmmonary responses by activation of the airway receptor, but does not regulate the peripheral cardiac muscarinic receptors |
| 2.7.11.16 | ATP + CXCR4 receptor |
GRK6, the pathway is important in facilitating neutrophil retention in the bone marrow |
| 2.7.11.16 | ATP + dopamine D1 receptor |
rapid desensitization of the receptor by GRK4 and GRK6, Na+/H+ exchanger activity of the receptor, overview |
| 2.7.11.16 | ATP + dopamine D1 receptor |
dopamine D1 receptors in IEC-6 rapidly desensitize to D1-like agonist stimulation and GRK 6 isozymes A and B, but not GRK 4, appear to be involved in agonist-mediated responsiveness and desensitization |
| 2.7.11.16 | ATP + dopamine D1 receptor |
GRK4 |
