EC Number |
Natural Substrates |
---|
2.7.1.150 | ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate |
- |
2.7.1.150 | ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate |
phosphatidylinositol(3,5)bisphosphate is essential for cellular responses to various stresses and for the mating pheromone signalling under starvation conditions |
2.7.1.150 | ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate |
stress-activated enzyme |
2.7.1.150 | ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate |
essential for vacuole function |
2.7.1.150 | ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate |
generation of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate is regulated by Vac7 protein, whereas turnover of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate is mediated in part by the Sac1 polyphosphoinositide phosphatase family member Fig4 |
2.7.1.150 | ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate |
reaction is essential for retrograde trafficking between the vacuole/lysosome and the late endosome and also for trafficking of some proteins into the vacuole via multivesicular bodies, enzyme synthesis is regulated by vac14 and vac7, 2 upstream activators, physiological roles of the enzyme and regulation mechnaism, overview |
2.7.1.150 | ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate |
regulation of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate synthesis involving osmotic stress, interleukins, UV radiation, and autophosphorylation, overview |
2.7.1.150 | ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate |
regulation of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate synthesis involving osmotic stress, overview |
2.7.1.150 | ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate |
regulation of 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate synthesis involving osmotic stress, overview, enzymes hydrolyzing the product are counteracting, overview |
2.7.1.150 | ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate |
Fab1 phosphatidylinositol 3-phosphate 5-kinase controls trafficking but not silencing of endocytosed receptors. Drosophila fab1 mutants contain undetectable phosphatidylinositol 3,5-bisphosphate levels, show profound increases in cell and organ size, and die at the pupal stage |