EC Number   |
Natural Substrates |
|---|
   2.4.2.31 | actin + NAD+ |
the ADP ribosylation of actin in the heterophils may be involved in the cellular processes such as phagocytosis, secretion and migration |
| 2.4.2.31 | FGF-2 + NAD+ |
ADP-ribosylation of FGF-2 may provide an additional level of control of FGF-2 activity |
| 2.4.2.31 | histone + NAD+ |
isozyme ART2 is active with high and low molecular weight histones, membrane-bound and PI-PLC released ART2 preferentially ADP-ribosylate high or low MW histones, respectively |
| 2.4.2.31 | human neutrophil peptide-1 + NAD+ |
human neutrophil peptide-1, HNP-1, from neutrophil cell surface, ADP-ribosylation of HNP-1 is primarily an activity of ART1 and occurs in inflammatory conditions and disease, lack of modified HNP-1 due to enzyme deficiency in the sputum leads to cystic fibrosis |
| 2.4.2.31 | more |
regulation of cytotoxic T cell functions |
| 2.4.2.31 | more |
the enzyme might be involved in regulating T cell and immune system activity |
| 2.4.2.31 | more |
enzyme is involved in posttranslational modification of proteins |
| 2.4.2.31 | more |
involved in immune regulation |
| 2.4.2.31 | more |
protein mono-ADP-ribosylation is a reversible post-translational modification that plays a role in regulation of cellular activities specific amino acid of the acceptor protein, overview |
| 2.4.2.31 | more |
the enzyme also shows auto-ADP-ribosylation activity |
