EC Number   |
Natural Substrates |
|---|
    2.4.1.83 | GDP-alpha-D-mannose + dolichyl phosphate |
- |
| 2.4.1.83 | GDP-mannose + dolichyl phosphate |
cAMP-dependent protein kinase is essential for upregulating the Dol-P-Man synthase activity and consequently the Glc3Man9GlcNAc-PP-Dol biosymthesis and protein N-glycosylation in cAMP-responsive cells |
| 2.4.1.83 | GDP-mannose + dolichyl phosphate |
the enzyme transfers mannose from the water soluble cytoplasmic donor GDP-Man, to the membrane bound, extremely hydrophobic, and long-chain polyisoprenoid acceptor, dolichyl-phosphate |
| 2.4.1.83 | GDPmannose + dolichyl phosphate |
essential enzyme in glycoprotein biosynthesis |
| 2.4.1.83 | GDPmannose + dolichyl phosphate |
the enzyme is involved in glycoconjugate biosynthesis |
| 2.4.1.83 | GDPmannose + dolichyl phosphate |
cAMP-mediated protein phosphorylation of microsomal membranes increases mannosylphosphodolichol synthase activity |
| 2.4.1.83 | GDPmannose + dolichyl phosphate |
synthesis of dolichol-phosphate mannose, a key mannosyl donor for the biosynthesis of N-linked oligosaccharides as well as for O-linked oligosaccharides on yeast glycoproteins |
| 2.4.1.83 | more |
increased availability of GDP-mannose corrects glycosylation defects in the endoplasmic reticulum, such as dolichyl D-mannosyl phosphate formation in dolichyl-phosphate beta-D-mannosyltransferase mutants of Saccharomyces cerevisiae |
