EC Number   |
Natural Substrates |
|---|
   2.4.1.150 | more |
initiates formation of side chains, key enzyme in biosynthesis of I antigen of erythrocytes, N-acetyllactosamine is a more physiological acceptor than lactose |
| 2.4.1.150 | more |
expression of I-antigen is entirely dependent on IGnT, expression of IGnT is developmentally regulated |
| 2.4.1.150 | more |
C2GnT forms the core 2 O-glycan branch, which is critical for oligosaccharide-mediated cell-cell interaction, IGnT forms the I antigen, both are members of a beta-1,6-N-acetylglucosaminyltransferase gene family |
| 2.4.1.150 | more |
the enzyme should mostly be responsible for making distal I-branch structures on poly-N-acetyllactosamine sequences in small intestine, as well as making mucin core 2 and core 4 structures, it alos has high C2/C4GnT activities |
| 2.4.1.150 | more |
a major enzyme involved in the branching of poly-N-acetyllactosamine chains in embryoglycan, branching of poly-N-acetyllactosamine chains is performed by beta1,6-N-acetylglucosaminylation of the galactosyl residue |
| 2.4.1.150 | UDP-N-acetyl-D-glucosamine + oligo-N-acetyllactosaminoglycan |
involved in midchain branching of oligo-N-acetyllactosaminoglycans by transferring GlcNAc in beta1,6-linkage to internal galactose residues |
| 2.4.1.150 | UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine |
responsible for the conversion of linear to branched polylactosamines, cIGnT6 actions at central rather than peridistal galactose residues of linear polylactosamines in the biosynthesis of blood group I antigens |
| 2.4.1.150 | UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine |
forms branches in poly-N-acetyllactosamines, which bear the I blood group antigen |
| 2.4.1.150 | UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosamine |
responsible for the formation of the beta1-6-branched poly-N-acetyllactosamine structure, involved in generating branches to central positions of preformed as well as growing polylactosamine chains but not in synthesizing the distal branches to growing chains |
| 2.4.1.150 | UDP-N-acetyl-D-glucosamine + poly-N-acetyllactosaminoglycan |
might function in biosynthesis of cell surface polylactosaminoglycans on Novikoff cells and blood group I antigenic structures, formation of the GlcNAcbeta(1-3)(GlcNAcbeta(1-6))Gal-R branching points in the branched type of polylactosylaminoglycans |
