EC Number |
Natural Substrates |
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2.4.1.129 | more |
overproduction of the inactive PBP1B variants causes lysis of wild-type cells |
2.4.1.129 | more |
penicillin-binding protein 1b is the key enzyme responsible for the formation of the polysaccharide backbone of the peptidoglycan as well as for cross-linking of its peptide portion |
2.4.1.129 | more |
the enzyme is both an amidase and an endopeptidase. The enzyme is a lytic transglycosylase that degrades the glycan strands of the peptidoglycan into disaccharide units. The enzyme binds the cell wall, but only cleaves the glycan strands after the stem peptides have been removed. The enzyme alone is unable to cleave purified peptidoglycan but needs the presence of SpoIIP |
2.4.1.129 | more |
lipid II, i.e. undecaprenyl-diphosphoryl-MurNAc(pentapeptide)-GlcNAc, is polymerized by the glycosyltransferase reaction, under the release of undecaprenol diphosphate |
2.4.1.129 | more |
natural substrate is lipid II |
2.4.1.129 | [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol |
- |
2.4.1.129 | [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol |
peptidoglycan-synthetic enzyme activities of penicillin-binding protein 3 may by involved in the process of cell division |
2.4.1.129 | [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol |
gram-positive cocci have cell wall peptidoglycan which seems to be synthesized by penicillin-binding protein transpeptidases and a separate transglycosylase |
2.4.1.129 | [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol |
enzyme is involved in synthesis of peptidoglycan |
2.4.1.129 | [GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)]n-diphosphoundecaprenol + GlcNAc-(1-4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol |
PBP4 is dispensable and that, as in other bacteria, its absence can be compensated for by the second class A PBP, PBP1 |