EC Number   |
Natural Substrates |
|---|
    2.3.3.5 | acetyl-CoA + H2O + oxaloacetate |
bifunctional enzyme with 2.3-fold higher activity as a 2-methylcitrate synthase |
| 2.3.3.5 | more |
key enzyme of the methylcitrate cycle and required for fungal propionate degradation |
| 2.3.3.5 | propanoyl-CoA + H2O + oxaloacetate |
- |
| 2.3.3.5 | propanoyl-CoA + H2O + oxaloacetate |
physiological role of the methylcitric acid cycle is a catabolic reaction sequence concerning the oxidation of propionate into pyruvate, regulatory enzyme of this cycle |
| 2.3.3.5 | propanoyl-CoA + H2O + oxaloacetate |
first key enzyme of the methylcitric acid cycle |
| 2.3.3.5 | propanoyl-CoA + H2O + oxaloacetate |
2-methylcitrate pathway is the major pathway of propionate metabolism |
| 2.3.3.5 | propanoyl-CoA + H2O + oxaloacetate |
implicated in the metabolism of propionate |
| 2.3.3.5 | propanoyl-CoA + H2O + oxaloacetate |
reaction is followed by isomerization of (2S,3S)-2-methylcitrate, i.e. (2S,3S)-2-hydroxybutane-1,2,3-tricarboxylate, to (2R,3S)-2-methylisocitrate, i.e. (2R,3S)-2-hydroxybutane-1,2,3-tricarboxylate, via cis-2-methylaconitate, key enzyme in the methylcitrate cycle for alpha-oxidation of propionate to pyruvate, overview |
| 2.3.3.5 | propanoyl-CoA + H2O + oxaloacetate |
bifunctional enzyme with 2.3-fold higher activity as a 2-methylcitrate synthase (reaction of EC 2.3.3.16) |
| 2.3.3.5 | propanoyl-CoA + H2O + oxaloacetate |
the enzyme is involved in the 2-methylcitrate cycle pathway which plays a significant role in the detoxification of propionyl-CoA in bacteria |
