EC Number |
Natural Substrates |
---|
2.3.1.26 | acyl-CoA + cholesterol |
- |
2.3.1.26 | acyl-CoA + cholesterol |
ACAT-1 plays an important role in the formation of macrophage-derived foam cells in atherosclerotic lesions |
2.3.1.26 | long-chain fatty acyl-CoA + cholesterol |
- |
2.3.1.26 | long-chain fatty acyl-CoA + cholesterol |
may play an important role in regulation of the accumulation of cholesterol esters within smooth muscle cells of the artery wall during atherogenesis and in synthesis of cholesterol esters during hepatic very low-density lipoprotein synthesis and secretion |
2.3.1.26 | long-chain fatty acyl-CoA + cholesterol |
responsible for cellular synthesis of cholesterol esters in various cell types |
2.3.1.26 | long-chain fatty acyl-CoA + cholesterol |
role in lipoprotein metabolism and atherogenesis |
2.3.1.26 | long-chain fatty acyl-CoA + cholesterol |
the enzyme is relevant for cellular cholesterol esterification in vivo, the regulation in human mononuclear phagocytes indicates that the enzyme is also involved in foam cell formation during early atherogenesis |
2.3.1.26 | long-chain fatty acyl-CoA + cholesterol |
the high activity of intestinal enzyme renders it possible that the enzyme plays a role in cholesterol absorption |
2.3.1.26 | long-chain fatty acyl-CoA + cholesterol |
the enzyme plays an important role in maintenance of hepatic cholesterol homeostasis |
2.3.1.26 | more |
two closely related enzymes identified that catalyse the esterification of cholesterol using acyl-CoA substrates, namely ACAT1 and ACAT2, the orientation of ACAT2 in the endoplasmic reticulum membrane, in addition to its expression only in liver and intestine, suggests that this enzyme may have as a primary function, the secretion of cholesteryl esters into apolipoprotein B-containing lipoproteins |