EC Number |
Natural Substrates |
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2.3.1.147 | more |
- |
2.3.1.147 | more |
EC 2.3.1.147 and 14000 MW phospholipase A act in a cooperative fashion in the production of platelet-activating factor in inflammatory cells |
2.3.1.147 | more |
inhibition of the enzyme can be linked to blockade of proliferation and the induction of apoptosis in HL-60 cells |
2.3.1.147 | more |
the enzyme is considered to play an important role in the reacylation of ether-containing phospholipids to provide polyunsaturated fatty acid containing ether phospholipids |
2.3.1.147 | more |
the reaction is extremely important in the remodeling of phospholipid molecular species and the mobilization of arachidonate into ether-linked lipids. The transfer of arachidonate to 1-alkyl-2-lyso-sn-glycero-3-phosphocholine is important in the final inactivation step for platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine), whereby 1-alkyl-2-arachidonoyl-sn-glycerol-3-phosphocholine, a stored precursor of both platelet activating factor and arachidonic acid metabolites is formed |
2.3.1.147 | more |
the enzyme mediates the movement of arachidonate into the large pool of 1-ether-linked phospholipids in human neutrophils |
2.3.1.147 | more |
the enzyme is important for the production of inflammatory lipid mediators in stimulated cells |
2.3.1.147 | more |
key enzyme responsible for the prolonged generation of lyso-platelet-activating factor that increases capability of CoA-independent transacylation followed by CoA-dependent acetylation of lyso-platelet-activating factor, can sustain the biosynthesis of platelet activating factor in lipopolysaccharide-stimulated IC-21 macrophages |
2.3.1.147 | more |
blockade of the enzyme, which leads to inhibition of arachidonate remodelling between phospholipids, results in the attenuation of platelet-activating factor production, arachidonic acid release and the formation of eicosanoid products |
2.3.1.147 | more |
the enzyme is the key mediator of arachidonate remodeling |