EC Number   |
Natural Substrates |
|---|
    2.1.2.3 | 10-formyl-7,8-dihydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide |
10-formyl-7,8-dihydrofolate is the in vivo substrate for AICAR transformylase |
| 2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazole-4-carboxamide |
penultimate step of the purine de novo synthesis pathway |
| 2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide |
- |
| 2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide |
precursors for inosinic acid biosynthesis |
| 2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide |
penultimate and final steps in the de novo purine biosynthesis pathway |
| 2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide |
de novo synthesis of purine nucleotides |
| 2.1.2.3 | 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-imidazolecarboxamide |
reduced folate cofactor requiring step of de novo purine biosynthesis |
| 2.1.2.3 | 10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide |
- |
| 2.1.2.3 | more |
polymorphisms in 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene is not associated with recurrent venous thrombosis risk |
| 2.1.2.3 | more |
10-formyl-7,8-dihydrofolate, not 10-formyl-5,6,7,8-tetrahydrofolate, is the predominant in vivo substrate for mammalian aminoimidazolecarboxamide ribotide transformylase. Bioactivity of the unnatural isomer [6R]-5-formyltetrahydrofolate is in vivo converted to 10-formyl-7,8-dihydrofolate and serves thus as a substrate |
