EC Number   |
Natural Substrates |
|---|
   2.1.1.6 | 4-hydroxyestradiol + S-adenosyl-L-methionine |
MCF-10F cells oxidize 4-hydroxyestradiol to estrone (estradiol)-3,4-quinones, which react with DNA to form the depurinating N3Ade and N7Gua adducts |
| 2.1.1.6 | 4-hydroxyestradiol + S-adenosyl-L-methionine |
in the mammary gland, catechol estrogens are predominately inactivated by catechol-O-methyltransferase. in the isoflavone-induced. The estrogen receptor is involved in the down-regulation of COMT expression |
| 2.1.1.6 | homoprotocatechuic acid + S-adenosyl-L-methionine |
- |
| 2.1.1.6 | more |
activity in cells expressing norepinephrine transporter |
| 2.1.1.6 | more |
comparison of wild type and variant isoforms and implications for estrogen levels |
| 2.1.1.6 | more |
physiological role is the inactivation of catecholamine hormones and neurotransmitters as well as detoxification of a variety of xenobiotic amines and drugs |
| 2.1.1.6 | more |
membrane protein and (or) lipid components may play an important role in catecholamine metabolism |
| 2.1.1.6 | more |
primary role in extraneuronal inactivation of endogenous catecholamines and in the further metabolism of oxidized catecholamine metabolites |
| 2.1.1.6 | more |
COMT in the adrenal gland might not be related to blood pressure regulation |
| 2.1.1.6 | more |
constitutive enzyme may play an important role in detoxification of polycyclic aromatic hydrocarbons |
