EC Number   |
Natural Substrates |
|---|
    2.1.1.28 | 9-methylnorharman + S-adenosyl-L-methionine |
PNMT catalyzes the 2N-methylation of beta-carbolines, forming 2N-methylated beta-carbolinium cations, which are structural and functional analogs of the Parkinsonian-inducing toxin MPP+ |
| 2.1.1.28 | more |
final enzyme in the pathway for epinephrine biosynthesis |
| 2.1.1.28 | more |
enzyme is involved in biosynthesis of epinephrine |
| 2.1.1.28 | more |
terminal enzyme in epinephrine biosynthesis |
| 2.1.1.28 | more |
terminal enzyme in the biosynthetic pathway for epinephrine |
| 2.1.1.28 | more |
the phenylethanolamine N-methyltransferase GRE plays a necessary, but not sufficient role in the transcriptional aspects to the control mechanism. Analyses implicate the participation of sequences in the distal 5´promoter of this gene. |
| 2.1.1.28 | more |
the enzyme binds to the alpha-adrenoreceptor |
| 2.1.1.28 | more |
the enzyme is involved in norepinephrine pathways |
| 2.1.1.28 | S-adenosyl-L-methionine + norepinephrine |
epinephrine is an important neurotransmitter and hormone, and epinephrine is required for normal blood pressure and cardiac filling responses to stress, but is not required for tachycardia during stress or normal cardiovascular function at rest |
| 2.1.1.28 | S-adenosyl-L-methionine + norepinephrine |
last step in biosynthesis of epinephrine |
