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Results 1 - 10 of 28 > >>
EC Number Natural Substrates Commentary (Nat. Sub.)
Show all pathways known for 1.6.5.2Display the word mapDisplay the reaction diagram Show all sequences 1.6.5.2more lack of NQO1 in male mice increases benzene-induced hematotoxicity but not genotoxicity or the DNA damage response. NQO1 appears critical in female mice for detoxifying the metabolites of benzene responsible for genotoxicity, hematotoxicity, and induction of the DNA damage response
Show all pathways known for 1.6.5.2Display the word mapDisplay the reaction diagram Show all sequences 1.6.5.2more NQO1 activity colocalizes closely with Alzheimer‘s disease pathology supporting a presumed role as an antioxidant system upregulated in response to the oxidative stress of the Alzheimer‘s disease process
Show all pathways known for 1.6.5.2Display the word mapDisplay the reaction diagram Show all sequences 1.6.5.2more plays one of the main roles in the bioactivation of quinoidal drugs
Show all pathways known for 1.6.5.2Display the word mapDisplay the reaction diagram Show all sequences 1.6.5.2more regeneration of alpha-tocopherol may be one of the physiologic functions of this enzyme
Show all pathways known for 1.6.5.2Display the word mapDisplay the reaction diagram Show all sequences 1.6.5.2more the enzyme is involved in the metabolic activation of carcinogenic aristolochic acid
Show all pathways known for 1.6.5.2Display the word mapDisplay the reaction diagram Show all sequences 1.6.5.2more the main cytotoxicity mechanism of antitumour aziridinyl-benzoquinones is their two-electron reduction to alkylating products by NAD(P)H:quinone oxidoreductase. In addition to the activation of NQO1 the oxidative stress, presumably initiated by single-electron enzymatic reduction, plays an important role in the cytotoxicity of aziridinyl-substituted quinones
Show all pathways known for 1.6.5.2Display the word mapDisplay the reaction diagram Show all sequences 1.6.5.2more enzyme contributes to the capacity of keratinocytes to protect epidermis against oxidant stress
Show all pathways known for 1.6.5.2Display the word mapDisplay the reaction diagram Show all sequences 1.6.5.2more increased enzyme expression reflects an endogenous defense response against reactive oxygen species-mediated cellular toxicity
Show all pathways known for 1.6.5.2Display the word mapDisplay the reaction diagram Show all sequences 1.6.5.2more role of enzyme in protecting against environmental stressors
Show all pathways known for 1.6.5.2Display the word mapDisplay the reaction diagram Show all sequences 1.6.5.2more ChrR minimizes intracellular H2O2 stress
Results 1 - 10 of 28 > >>