EC Number   |
Natural Substrates |
|---|
    1.5.3.16 | more |
no activity with spermidine |
| 1.5.3.16 | more |
no oxidation activity with spermidine |
| 1.5.3.16 | more |
AtPAO4 deficiency induces alterations in the expression of genes related to the drought stress response and flavonoid biosynthesis |
| 1.5.3.16 | more |
in mammalian cells, polyamine catabolism seems to be mediated by the activity of two enzymes, PAO and SMO |
| 1.5.3.16 | more |
PAOh1 is upregulated in response to polyamine analogue exposure. N1,N11-bis(ethyl)norspermine results in 5fold induction of PAO mRNA and a more than 3-fold induction of PAO activity |
| 1.5.3.16 | more |
spermine oxidase activity is a direct oxidative stress inducer of DNA damage, thus rendering cells more sensitive to radiation and apoptosis |
| 1.5.3.16 | more |
spermine oxidase overactivity can deliver sublethal chronic DNA damage and repair without affecting transcriptional and enzymatic levels of the PA key regulatory enzymes ornithine decarboxylase and spermidine/spermine N1-acetyltransferase |
| 1.5.3.16 | more |
the major level of control of SMO(PAOh1) expression in response to polyamine analogues exposure is at the level of mRNA |
| 1.5.3.16 | more |
TNF-alpha exposure leads to the induction of SMO/PAOh1, which produces sufficient H2O2 to result in potentially mutagenic DNA damage and presents a molecular mechanism by which general inflammation can contribute directly to the development of cancer |
| 1.5.3.16 | more |
peroxisomal polyamine oxidase AtPAO4 is involved in the catabolism of polyamines in leaves, overview |
