EC Number   |
Natural Substrates |
|---|
    1.5.1.34 | 5,6,7,8-tetrahydropteridine + NAD(P)+ |
enzyme is required for recycling of 6,7-dihydropteridine, in vivo regulation is related to growth phase |
| 1.5.1.34 | 6,7-dihydropteridine + NADH |
last step of recycling of the cofactor (6R)-L-erythro-5,6,7,8-tetrahydrobiopteridine essential for aromatic amino acid hydroxylases and nitric oxide synthases, regulatory mechanism involve H2O2, enzyme inactivation because of H2O2 accumulation in the epidermis contributes to the pathomechanism of vitiligo |
| 1.5.1.34 | 6,7-dihydropteridine + NADPH + H+ |
- |
| 1.5.1.34 | a 6,7-dihydropteridine + NAD(P)H + H+ |
- |
| 1.5.1.34 | dihydrobiopterin + NADH + H+ |
pH 7.4, 37°C |
| 1.5.1.34 | more |
essential part of the hydroxylating system of the aromatic amino acids phenylalanine, tyrosine and tryptophan, reduces quinonoid dihydropterine to regenerate tetrahydrobiopterin, main metabolic derangements caused by DHPR deficiency are hyperphenylalaninaemia and impaired production of the monoamine neurotransmitters dopamine, noradrenaline and serotonin, DHPR deficiency patients can develop severe and progressive neurological damage |
| 1.5.1.34 | more |
in vivo role as dihydropteridine reductase involved in aromatic amino acids metabolism suggested |
| 1.5.1.34 | quinoid 7,8-(6H)-dihydropterin + NADH + H+ |
non-enzymatic reaction of quinoid 7,8-(6H)-dihydropterine to 7,8-dihydropterin |
| 1.5.1.34 | quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H |
- |
| 1.5.1.34 | quinonoid 7,8-(6H)-dihydrobiopterin + NAD(P)H |
may also have an important role in regulation of catecholamine synthesis |
