EC Number   |
Natural Substrates |
|---|
  1.4.1.8 | L-valine + NAD(P)+ + H2O |
- |
| 1.4.1.8 | L-valine + NAD(P)+ + H2O |
VDH2 rather than VDH1 plays a role in metabolism of branched chain amino acids and thus in tylosin biosynthesis, expression of VDH1 is unstable |
| 1.4.1.8 | L-valine + NAD(P)+ + H2O |
metabolic connection between valine catabolism and biosynthesis of macrolide or polyether antibiotics |
| 1.4.1.8 | L-valine + NAD(P)+ + H2O |
VDH is required for utilization of branched chain amino acids, the catabolism appears to be an alternative source of n-butyrate, 2-methylmalonate, and propionate needed for biosynthesis of macrolide and polyether antibiotics |
| 1.4.1.8 | L-valine + NAD(P)+ + H2O |
regulatory enzyme involved in biosynthesis of n-butyrate, a building unit of the oligoketide antibiotic tylosin, NAD+ as natural cofactor for oxidative deamination |
| 1.4.1.8 | L-valine + NAD(P)+ + H2O |
first catabolic step of L-valine and some other branched chain L-amino acids, important role in providing precursors for biosynthesis of polyether antibiotic, salinomycin, that is produced at a high level |
| 1.4.1.8 | L-valine + NAD(P)+ + H2O |
first step in valine catabolism |
| 1.4.1.8 | L-valine + NAD(P)+ + H2O |
two forms of enzyme activity: enzyme associated with subcellular structures in shoots or leaves probably plays a biosynthetic role for valine production and the soluble enzyme in roots plays a degradative role in valine catabolism |
