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Results 1 - 9 of 9
EC Number Natural Substrates Commentary (Nat. Sub.)
Display the reaction diagram Show all sequences 1.14.99.52hercynine + gamma-L-glutamyl-L-cysteine + O2 -
Display the reaction diagram Show all sequences 1.14.99.52hercynine + L-cysteine + O2 -
Display the reaction diagram Show all sequences 1.14.99.52hercynine + L-cysteine + O2 reaction of EC 1.14.99.51
Display the reaction diagram Show all sequences 1.14.99.52L-histidine + L-cysteine + O2 -
Display the reaction diagram Show all sequences 1.14.99.52more besides catalyzing the four-electron oxidative coupling between histidine and cysteine, enzyme OvoA can also catalyze a direct oxidative coupling between hercynine and cysteine, which can shorten the ergothioneine biosynthetic pathway by two steps. Enzyme OvoA can also catalyze the reaction of egtB between hercynine and gamma-L-glutamyl-L-cysteine, EC 1.14.99.50
Display the reaction diagram Show all sequences 1.14.99.52more an OvoA-like protein, full-length OvoA homologue, OvoA_2, is a monofunctional sulfoxide synthase
Display the reaction diagram Show all sequences 1.14.99.52more OvoA in ovothiol biosynthesis is a mononuclear non-heme iron enzyme catalyzing the oxidative coupling between L-histidine and L-cysteine. It can also catalyze the oxidative coupling between hercynine and cysteine, yet with a different regioselectivity (cf. Ec 1.14.99.51). OvoA can also catalyze the oxidation of cysteine to either cysteine sulfinic acid or cystine, OvoA has cysteine dioxygenase activity (cf. EC 1.13.11.20). A 3-His catalytic triad is a prerequisite for the cysteine dioxygenase activity
Display the reaction diagram Show all sequences 1.14.99.52more short cyanobacterial OvoA-type enzymes may contribute to ergothioneine (EC 1.14.99.51) instead of ovothiol production
Display the reaction diagram Show all sequences 1.14.99.52more the ovothiol biosynthetic sulfoxide synthase OvoA from Erwinia tasmaniensis (OvoAErwin) is a promiscuous enzyme. This enzyme is most efficient in making its native product S-(L-histidin-5-yl)-L-cysteine S-oxide, but, when presented with N-alpha-trimethylhistidine as a sulfur acceptor, the enzyme switches product specificity and produces gamma-L-glutamyl-S-(hercyn-2-yl)-L-cysteine S-oxide albeit with significantly lower efficiency
Results 1 - 9 of 9