EC Number |
Natural Substrates |
---|
1.14.16.4 | L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 |
- |
1.14.16.4 | L-tryptophan + (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + O2 |
over 300 single nucleotide polymorphisms have been identified and are associated with symptoms ranging from mild hyperphenylalaninemia to severe phenylketonuria |
1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
- |
1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
brain-specific isozyme TPH2 is the rate-limiting enzyme in serotonin biosynthesis, a truncated enzyme version occurs in brain tissues being the cause of impaired serotonin transmission |
1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
differences in the regulation of isozyme TPH2 versus isozyme TPH1, overview |
1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
first and rate limiting step in the biosynthesis of the neurotransmitter serotonin |
1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
first and rate-determining step in the biosynthesis of the neurotransmitter serotonin |
1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
first and rate-limiting step in serotonin biosynthesis, overview. Serotonin, i.e. 5-hydroxytryptamine, is a neurotransmitter that modulates central and peripheral functions through action on neurons, smooth muscle, and other cell types |
1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
first and rate-limiting step in serotonin biosynthesis, serotonin, i.e. 5-hydroxytryptamine, is a neurotransmitter with both central and peripheral functions, including the modulation of mood, appetite, hemodynamics, gastrointestinal sensation, secretion, and motility |
1.14.16.4 | L-tryptophan + tetrahydrobiopterin + O2 |
initial and rate-limiting enzyme in the biosynthesis of serotonin |