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Results 1 - 9 of 9

EC Number	Natural Substrates	Commentary (Nat. Sub.)
1.14.14.B11	(R)-nicotine + O2 + [reduced NADPH-hemoprotein reductase] + O2	isoforms CYP82E4, CYP82E5v2, and CYP82E10 demethylate (R)-nicotine 3, 10, and 10fold faster than (S)-nicotine, respectively
1.14.14.B11	(S)-nicotine + [reduced NADPH-hemoprotein reductase] + O2	-
1.14.14.B11	(S)-nicotine + [reduced NADPH-hemoprotein reductase] + O2	CYP82E4 selectively demethylates (S)-nicotine
1.14.14.B11	(S)-nicotine + [reduced NADPH-hemoprotein reductase] + O2	only isoform CYP82E4 can significantly convert (S)-nicotine to (S)-nornicotine
1.14.14.B11	nicotine + NADPH + H+	-
1.14.14.B11	nicotine + NADPH + O2 + H+	demethylates nicotine to form nornicotine, a precursor to the nitrosamine N'-nitrosonornicotine
1.14.14.B11	nicotine + O2 + [reduced NADPH-hemoprotein reductase] + O2	-
1.14.14.B11	nicotine + [reduced NADPH-hemoprotein reductase] + O2	-
1.14.14.B11	nicotine + [reduced NADPH-hemoprotein reductase] + O2	nornicotine is a secondary tobacco alkaloid that is produced by the N-demethylation of nicotine. Nornicotine production and accumulation in tobacco are undesirable because nornicotine serves as the precursor in the synthesis of the carcinogen N-nitrosonornicotine during the curing and processing of tobacco

Results 1 - 9 of 9

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Release 2023.1 (January 2023)