EC Number   |
Natural Substrates |
|---|
    1.14.14.23 | 7-dehydrocholesterol + NADPH + H+ |
- |
| 1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 |
- |
| 1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 |
rate-limiting step in bile acid formation |
| 1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 |
first step of cholesterol catabolism |
| 1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 |
first step of cholesterol catabolism, rate-limiting and major regulatory enzyme in the synthesis of bile acids |
| 1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 |
first step of cholesterol catabolism, rate-limiting enzyme in the classical pathway of bile acid synthesis |
| 1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 |
CYP7A1 is a rate-limiting enzyme in bile acid synthesis and therefore plays an important role in maintaining cholesterol homeostasis, cholesterol metabolism, overview |
| 1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 |
first and rate-limiting step in the neutral pathway of cholesterol metabolism |
| 1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 |
insulin, forkhead box O1, and sterol regulatory element-binding protein 1c are involved in regulation of expression of gene CYP7A1, genetic mechanism, overview |
| 1.14.14.23 | cholesterol + [reduced NADPH-hemoprotein reductase] + O2 |
rate-limiting enzyme in cholesterol conversion to bile acids |
