EC Number   |
Natural Substrates |
|---|
    1.14.14.1 | 4-(methylnitrosamino)-1-(3pyridyl)-1-butanone + [reduced NADPH-hemoprotein reductase] + O2 |
nicotine oxidase activity of CYP2A6, activates the tobacco-derived carcinogens to mutagenic products |
| 1.14.14.1 | 7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2 |
7-ethoxycoumarin O-deethylation |
| 1.14.14.1 | 7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2 |
- |
| 1.14.14.1 | 7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2 |
wild-type enzyme and recombinant enzyme CYP1A1 fused to yeast reductase and expressed in transgenic tobacco plants |
| 1.14.14.1 | 7-ethoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2 |
wild-type enzyme and recombinant enzyme P4502B6 fused to yeast reductase and expressed in transgenic tobacco plants |
| 1.14.14.1 | 7-ethoxyresorufin + [reduced NADPH-hemoprotein reductase] + O2 |
7-ethoxyresorufin O-deethylation |
| 1.14.14.1 | 7-methoxycoumarin + [reduced NADPH-hemoprotein reductase] + O2 |
- |
| 1.14.14.1 | aflatoxin B1 + [reduced NADPH-hemoprotein reductase] + O2 |
i.e. AFB1, bioactivation of the carcinogenic mycotoxin to a toxic compound, although not acutely toxic at low concentrations, AFB1 had significant chronic effects, including protracted development, increased mortality, decreased pupation rate, and reduced pupal weight, sensitivity varies with developmental stage, whereas intermediate concentrations causes complete mortality in first instars, this same concentration has no detectable adverse effects on larvae encountering AFB1 in fifth instar. These compounds owe their toxicity to their ability to form irreversible adducts to nucleic acids with the concomitant inhibition of DNA replication and DNA-dependent transcription, mortality, overview |
| 1.14.14.1 | aminopyrine + [reduced NADPH-hemoprotein reductase] + O2 |
aminopyrene-N-demethylation |
| 1.14.14.1 | arachidonic acid + O2 + NADPH |
- |
