EC Number   |
Natural Substrates |
|---|
    1.14.13.195 | L-lysine + NADPH + H+ + O2 |
- |
| 1.14.13.195 | L-ornithine + NADPH + H+ + O2 |
- |
| 1.14.13.195 | L-ornithine + NADPH + H+ + O2 |
first step in pyoverdine biosynthesis |
| 1.14.13.195 | L-ornithine + NADPH + H+ + O2 |
hydroxylation of the primary amine of ornithine in the initial step of the biosynthesis of siderophore pyoverdin |
| 1.14.13.195 | L-ornithine + NADPH + H+ + O2 |
one of the initial enzymes in the biosynthetic pathway of pyoverdine I the major siderophore produced by Pseudomonas aeruginosa PAO1 to import iron |
| 1.14.13.195 | L-ornithine + NADPH + H+ + O2 |
the enzyme is involved in biosynthesis of N5-acetyl-N5-hydroxy-L-ornithine, a building block of the hydroxamate-type siderophore erythrochelin |
| 1.14.13.195 | more |
PvdA is the ornithine hydroxylase, which performs the first enzymatic step in preparation of hydroxamate siderophore derivatives, pyoverdin is the hydroxamate siderophore produced by the opportunistic pathogen Pseudomonas aeruginosa under the iron-limiting conditions of the human host, overview. Poor activity with DL-2,3-diaminopropionic acid and D-ornithine, no activity with L-norleucine, 5-aminopentanoic acid, DL-2,4-diaminobutyric acid, and 1,4-diaminobutane, and no activity with NADH as cofactor, substrate specificity, overview |
