EC Number   |
Natural Substrates |
|---|
   1.14.11.27 | histone H3 N6,N6,N6-trimethyl-L-lysine26 + 2-oxoglutarate + O2 |
- |
| 1.14.11.27 | histone H3 N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 |
- |
| 1.14.11.27 | histone H3 N6,N6,N6-trimethyl-L-lysine9 + 2-oxoglutarate + O2 |
- |
| 1.14.11.27 | histone H3-N6,N6,N6-trimethyl-L-lysine36 + 2-oxoglutarate + O2 |
- |
| 1.14.11.27 | histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 |
- |
| 1.14.11.27 | histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 |
Jhdm1a is a histone demethylase that specifically demethylates dimethylated H3K36 |
| 1.14.11.27 | histone H3-N6,N6-dimethyl-L-lysine36 + 2-oxoglutarate + O2 |
KDM2b/JHDM1b is an H3K36me2-specific demethylase |
| 1.14.11.27 | more |
Ndy1 is a physiological inhibitor of senescence in dividing cells and inhibition of senescence depends on histone H3 demethylation |
| 1.14.11.27 | more |
dynamic nature of histone methylation regulation on four of the main lysine sites of methylation on histone H3 and H4 tails, i.e. H3K4, H3K9, H3K27 and H3K36, overview. Methylation of non-histone proteins may be a general means to regulate epigenetic information |
| 1.14.11.27 | more |
histone methyl-lysine marks display dynamic changes during the parasite asexual erythrocytic cycle, suggesting that they constitute an important epigenetic mechanism of gene regulation in malaria parasites |
