EC Number |
Natural Substrates |
---|
1.11.1.27 | 2 glutathione + H2O2 |
- |
1.11.1.27 | 2 glutathione + ROOH |
- |
1.11.1.27 | 2 GSH + ROOH |
glutathione is the primary native reductant |
1.11.1.27 | more |
Pf1-Cys-Prx protects the parasite against oxidative stress by binding to ferriprotoporphyrin |
1.11.1.27 | more |
the enzyme functions in antioxidant defense and lung phospholipid metabolism |
1.11.1.27 | more |
Tpx-1 is required for normal gametocyte development but does not affect the male/female gametocyte ratio or male gametogenesis |
1.11.1.27 | more |
peroxiredoxin 6 differs from other mammalian peroxiredoxins both in its ability to reduce phospholipid hydroperoxides at neutral pH and in having phospholipase A2 activity that is maximal at acidic pH |
1.11.1.27 | more |
Prx1 is particularly required to protect against mitochondrial oxidation, Prx1 requires thioredoxin reductase 2 and the glutathione system, but not thioredoxin 3, to promote oxidant resistance |
1.11.1.27 | more |
the 1-Cys Prdx type Prdx6, possessing a single conserved cysteine residue, shows heterodimerization with piGSH S-transferase as part of the catalytic cycle, and the ability to either reduce the oxidized sn-2 fatty acyl group of phospholipids (peroxidase activity) or to hydrolyze the sn-2 ester (alkyl) bond of phospholipids (PLA2 activity), thus exhiting peroxidase and phospholipase activities, overview. The bifunctional protein has separate active sites for both activities, namely a Cys 47-dependent peroxidase activity site and a Ser32-dependent PLA2 activity site. Substrate specificity, overview |