EC Number   |
Natural Substrates |
|---|
    1.1.1.41 | D-isocitrate + NAD+ |
- |
| 1.1.1.41 | DL-isocitrate + NAD+ |
- |
| 1.1.1.41 | isocitrate + NAD+ |
- |
| 1.1.1.41 | isocitrate + NAD+ |
enzyme has a regulatory role in the tricarboxylic cycle |
| 1.1.1.41 | isocitrate + NAD+ |
enzyme performs the rate-limiting step in the mitochondrial tricarboxylic cycle and is subject to complex allosteric regulation |
| 1.1.1.41 | isocitrate + NAD+ |
key enzyme in the Krebs cycle |
| 1.1.1.41 | isocitrate + NAD+ |
pyridine nucleotide contents in mitochondria and cytosol, regulation, overview |
| 1.1.1.41 | isocitrate + NAD+ |
IDH1 is an enzyme that catalyzes the oxidative decarboxylation of isocitrate into alpha-ketoglutarate utilizing either NAD+ or NADP+ as cosubstrates |
| 1.1.1.41 | more |
allosteric regulation, enzyme specifically binds to 5'-untranslated regions of yeast mitochondrial mRNAs, and transcripts containing these regions allosterically inhibit the enzyme, which can be relieved by activator AMP in presence of isocitrate, complex formation, overview |
| 1.1.1.41 | more |
enzyme is involved in tricarboxylic acid cycle and plays a key role in the regulation of biosynthesis of citrate and isocitrate, yeast is overproducing citrate under nitrogen deficiency in presence of glucose |
