EC Number   |
Natural Substrates |
|---|
   1.1.1.300 | 11-cis-retinal + NADPH + H+ |
- |
| 1.1.1.300 | 11-cis-retinol + NADP+ |
possibly involved in the production of 11-cis-retinal from 11-cis-retinol during regeneration of the cone visual pigments |
| 1.1.1.300 | 9-cis-retinol + NADP+ |
possibly involved in the first step of 9-cis-retinoic acid production |
| 1.1.1.300 | all-trans retinal + NADPH + H+ |
- |
| 1.1.1.300 | all-trans-retinal + NADPH + H+ |
- |
| 1.1.1.300 | all-trans-retinal + NADPH + H+ |
involved in the regeneration of bleached visual pigments in photoreceptor cells, involved in retinol metabolism outside of photoreceptor cells |
| 1.1.1.300 | all-trans-retinal + NADPH + H+ |
greater catalytic efficiency in the reductive than in the oxidative direction. Localization of RDH13 at the entrance to the mitochondrial matrix suggests that it may function to protect mitochondria against oxidative stress associated with the highly reactive retinaldehyde produced from dietary beta-carotene |
| 1.1.1.300 | all-trans-retinal + NADPH + H+ |
RDH12 is dispensable in support of the visual cycle but appears to be a key component in clearance of free all-trans-retinal, thereby preventing accumulation of N-retinylidene-N-retinylethanolamine (a toxic substance known to contribute to retinal degeneration) and photoreceptor cell death |
| 1.1.1.300 | all-trans-retinol + NADP+ |
- |
| 1.1.1.300 | all-trans-retinol + NADP+ |
the enzyme plays a role in retinoid metabolism |
