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EC Number
Natural Substrates
Commentary (Nat. Sub.)
alpha-Tubulin + H2O
splicing variant HDAC6p114 is intact in its deacetylase activity against a-tubulin
alpha-tubulin + H2O
conserved mechanism of histone deacetylase repression of some secondary metabolite gene clusters
histone deacetylases regulate the expression of HoxA9, which acts as a master switch to regulate the expression of prototypical endothelial-committed genes such as endothelial nitric oxide synthase, VE-cadherin, VEGF-R2, and mediates the shear stress-induced maturation of endothelial cells
isoform HDAC4 is an essential regulator of myofibroblastic differentiation
isoforms HDAC1 and HDAC2 are associated in vivo, complex is able to deacetylate all four core histones in vitro
acetylation of histone core proteins is regulated by HDAC, H3K9-K14 deacetylation is mediated, at least in part, by HDAC 11
deacetylation of tubulin
HDAC6 deacetylases tubulins, best noted substrate is beta-tubulin
HDACs catalyse the removal of acetyl groups from e-N-acetylated lysine residues of various protein substrates
Results 1 - 10 of 25 > >>