EC Number   |
Natural Substrates |
|---|
   3.2.2.20 | alkylated DNA + H2O |
- |
| 3.2.2.20 | more |
3-methyladenine DNA glycosylase recognizes and excises a broad range of purines damaged by alkylation and oxidative damage, including 3-methyladenine, 7-methylguanine, hypoxanthine, and 1,N6-ethenoadenine |
| 3.2.2.20 | alkylated DNA + H2O |
50% of DNA alkylation is repaired in the first 60 min after treatment with methyl methanesulfonate |
| 3.2.2.20 | more |
AlkC is involved exclusively in the repair of alkylation damage |
| 3.2.2.20 | alkylated DNA + H2O |
also removes 7-methylguanine |
| 3.2.2.20 | alkylated DNA + H2O |
cellular repair of alkylated DNA base modifications |
| 3.2.2.20 | alkylated DNA + H2O |
constititively expressed |
| 3.2.2.20 | alkylated DNA + H2O |
constitutive pathway for repair of DNA damaged by simple alkylating agents such as methylmethanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine |
| 3.2.2.20 | alkylated DNA + H2O |
double-stranded DNA is an effective substrate, enzyme is less efficient in excision of base damage from single-stranded regions transiently formed in DNA during transcription and replication |
| 3.2.2.20 | alkylated DNA + H2O |
highest activity by producing 3-methylguanine |
