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Results 1 - 10 of 16 > >>
EC Number
Natural Substrates
Commentary (Nat. Sub.)
alkylated DNA + H2O
-
alkylated DNA + H2O
important role in preventing the mutagenic effects of deaminated purines and cyclic etheno adducts
alkylated DNA + H2O
also removes 7-methylguanine
alkylated DNA + H2O
smallest member of the helix-hairpin-helix HhH superfamily of DNA glycosylases
alkylated DNA + H2O
double-stranded DNA is an effective substrate, enzyme is less efficient in excision of base damage from single-stranded regions transiently formed in DNA during transcription and replication
alkylated DNA + H2O
cellular repair of alkylated DNA base modifications
alkylated DNA + H2O
reaction of the enzyme with alkylated DNA leads to introduction of apurinic sites but no chain breaks
alkylated DNA + H2O
nuclear transcription factor estrogen receptor alpha interacts with 3-methyladenine DNA glycosylase to modulate transcription and DNA repair, enzyme catalyzes removal of hypoxanthine from DNA, estrogen receptor alpha stabilizes the interaction of the enzyme with hypoxanthine containing DNAand increases the catalytic removal of the modified base
alkylated DNA + H2O
primarily removes N3-methyladenine but also N3-methylguanine from DNA by glycosylic cleavage in the first step of the base excision repair
alkylated DNA + H2O
constitutive pathway for repair of DNA damaged by simple alkylating agents such as methylmethanesulfonate and N-methyl-N'-nitro-N-nitrosoguanidine
Results 1 - 10 of 16 > >>