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EC Number
Natural Substrates
Commentary (Nat. Sub.)
ATP + a G protein-coupled receptor
the GRKs are important in the cardiovascular system, the major G protein-coupled receptor regulatory pathway involves phosphorylation of activated receptors by GRKs, followed by binding of arrestin proteins, which prevent receptors from activating downstream heterotrimeric G protein pathways while allowing activation of arrestin-dependent signaling pathways, general mechanisms of GRK-arrestin regulation, overview, physiological functions and potential pathophysiological roles of GRKs and arrestins in human disorders, overview
ATP + alpha-synuclein
GRK5 phosphorylates Ser-129 of alpha-synuclein at the plasma membrane and induces translocation of phosphorylated alpha-synuclein to the perikaryal area, GRK5 promotes alpha-linolenic acid-induced oligomerization of alpha-synuclein, alpha-synuclein phosphorylation by GRK5 plays a crucial role in the pathogenesis of sporadic Parkinson's disease, sPD
ATP + ATP + G protein-coupled receptor
-
ATP + beta-adrenergic receptor
desensitization of the receptor by GRK4, GRK5, and GRK6
ATP + BLT1 receptor
GRK6, ablation of GRK6 leads to augmented signaling by leukotriene B4 acting through the BLT1 receptor
ATP + central M2 muscarinic receptor
desensitization of the receptor by GRK5, GRK5 regulates pulmmonary responses by activation of the airway receptor, but does not regulate the peripheral cardiac muscarinic receptors
ATP + CXCR4 receptor
GRK6, the pathway is important in facilitating neutrophil retention in the bone marrow
ATP + dopamine D1 receptor
rapid desensitization of the receptor by GRK4 and GRK6, Na+/H+ exchanger activity of the receptor, overview
ATP + dopamine D1 receptor
dopamine D1 receptors in IEC-6 rapidly desensitize to D1-like agonist stimulation and GRK 6 isozymes A and B, but not GRK 4, appear to be involved in agonist-mediated responsiveness and desensitization
ATP + dopamine D1 receptor
GRK4
Results 1 - 10 of 44 > >>