EC Number   |
Natural Substrates |
|---|
    2.1.1.355 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 |
overall reaction |
| 2.1.1.355 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 |
- |
| 2.1.1.355 | 3 S-adenosyl-L-methionine + a [histone H3]-L-lysine9 |
activity toward histones in chromatin. SUV39H1 trimethylates H3K9, thereby creating a binding site for HP1, which recruits SUV4-20H. This enzyme generates H4K20me3 using as a substrate the H4K20me1 generated by SET8. Consequently, SUV39H1 indirectly affects the methylation of H4K20 via two pathways: it modifies SET8, thereby enhancing its activity, and creates a site for the binding of SUV4-20H |
| 2.1.1.355 | more |
histone methylation has significant effects on heterochromatin formation and transcriptional regulation |
| 2.1.1.355 | more |
no activity is observed on trimethylated histone H3(K9) peptides either with or without ubiquitin |
| 2.1.1.355 | more |
the enzyme is automethylated at K239 |
| 2.1.1.355 | S-adenosyl-L-methionine + a [histone H3]-L-lysine9 |
- |
| 2.1.1.355 | S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 |
- |
| 2.1.1.355 | S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 |
preferred substrate |
| 2.1.1.355 | S-adenosyl-L-methionine + a [histone H3]-N6,N6-dimethyl-L-lysine9 |
the enzyme introduce H3K9me3 at pericentric heterochromatin |
