EC Number |
Natural Substrates |
---|
1.1.1.284 | formaldehyde + glutathione + NAD+ |
- |
1.1.1.284 | S-(hydroxymethyl)glutathione + NAD+ |
- |
1.1.1.284 | S-nitrosoglutathione + NAD(P)H + H+ |
- |
1.1.1.284 | S-nitrosoglutathione + NADH |
- |
1.1.1.284 | S-nitrosoglutathione + NADH + H+ |
- |
1.1.1.284 | S-nitrosoglutathione + NADPH + H+ |
- |
1.1.1.284 | S-nitrosoglutathione + NADH + H+ |
ADH3 can affect the transnitrosation equilibrium between S-nitrosoglutathione and S-nitrosated proteins, arguing for an important role in NO homeostasis |
1.1.1.284 | more |
alcohol dehydrogenase 3, ADH3, acts as S-nitrosylglutathione reductase catalyzing the NADH-dependent reduction of S-nitrosoglutathione to GSSG and NH3, but also shows detoxification of formaldehyde catalyzing the formation of S-formylglutathione from formaldehyde and GSH |
1.1.1.284 | 12-hydroxydodecanoic acid + glutathione + NAD+ |
best substrate for ADH3 |
1.1.1.284 | formaldehyde + glutathione + NAD+ |
enzymatic degradation of formaldehyde seems to play an important role in resistance against formaldehyde |