EC Number   |
Natural Substrates |
|---|
   3.4.22.38 | collagen I + H2O |
Cat K can degrade several bone matrix proteins including type I collagen during osteoclastic bone resorption |
| 3.4.22.38 | collagen I + H2O |
cathepsin K inhibition by cathepsin K inhibitor significantly increases the bone mineral density and the bone volume of the primary and secondary spongiosa, with a reduction of the urinary C-telopeptide of type I collagen that is increased by ovariectomized surgery compared to sham surgery, respectively, overview |
| 3.4.22.38 | collagen I + H2O |
cathepsin K is responsible for the degradation of type I collagen in osteoclast-mediated bone resorption. Cathepsin K interaction with type I collagen is required for 1. the release of cryptic Arg-Gly-Asp motifs during the initial attachment of osteoclasts and 2. termination of resorption via the creation of autocrine signals originating from type I collagen degradation, overview |
| 3.4.22.38 | collagen I + H2O |
cathepsin K is the only cathepsin that can degrade native type-I collagen in a triple-helix structure |
| 3.4.22.38 | collagen I + H2O |
cathepsin K regulates adipocyte differentiation, possible involvement of type I collagen degradation and regulation of collagen type I expression, molecular mechanism, overview |
| 3.4.22.38 | collagen I + H2O |
CatK is a cysteine protease expressed predominantly in osteoclastsosteoclasts, that plays a prominent role in degrading type I collagen. Growing CatK null mice have osteopetrosis associated with a reduced ability to degrade bone matrix |
| 3.4.22.38 | collagen I + H2O |
inhibition of cathepsin K reduces bone erosion, cartilage degradation and inflammation evoked by collagen-induced arthritis in mice, overview |
| 3.4.22.38 | collagen I + H2O |
osteoclasts degrade bone matrix by demineralization followed by degradation of type I collagen through secretion of the cysteine protease, cathepsin K |
| 3.4.22.38 | collagen I + H2O |
the lysosomal cysteine protease cathepsin K plays a key role in the degradation of the bone matrix, Cat K deficiency leads to an increase in bone mineral density |
| 3.4.22.38 | collagen II + H2O |
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