EC Number   |
Natural Substrates |
|---|
   3.4.21.53 | CysD + H2O |
a subunit of the sulfate adenylyltransferase, low activity |
| 3.4.21.53 | cystathionine beta-synthase + H2O |
when misfolded or unfolded |
| 3.4.21.53 | cytochrome c oxidase 4 isoform 1 + H2O |
i.e. COX4-1 |
| 3.4.21.53 | cytochrome c oxidase subunit + H2O |
- |
| 3.4.21.53 | glutaminase C + H2O |
when misfolded or unfolded |
| 3.4.21.53 | GlyA + H2O |
a protein of the MetR regulon |
| 3.4.21.53 | HrpG + H2O |
the degradation tag is located at the N-terminus of the substrate. The N-terminal moiety of HrpG is required for Lon recognition |
| 3.4.21.53 | IbpA + H2O |
- |
| 3.4.21.53 | LasI + H2O |
Lon is involved in the regulation of quorum-sensing signaling systems in Pseudomonas aeruginosa, the opportunistic human pathogen. The enzyme is part of the acyl-homoserine lactone-mediated QS system LasR/LasI, but LasR/LasI regulation is independent of the RhlR/RhlI system by Lon. QS systems are organized hierarchically: the RhlR/RhlI system is subordinate to LasR/LasI, Lon represses the expression of LasR/LasI by degrading LasI, an HSL synthase, leading to negative regulation of the RhlR/RhlI system, overview |
| 3.4.21.53 | MetR + H2O |
a protein of the MetR regulon, transcriptional regulator of metE expression |
