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EC Number Natural Substrates Commentary (Nat. Sub.)
Show all pathways known for 2.7.4.9Display the word mapDisplay the reaction diagram Show all sequences 2.7.4.9more multifunctional enzyme which also phosphorylates pyrimidine nucleosides, pyrimidine nucleoside monophosphates, and several nucleoside analogues
Show all pathways known for 2.7.4.9Display the word mapDisplay the reaction diagram Show all sequences 2.7.4.9thymidine monophosphate + ATP Thymidylate kinase (TMK) (E.C. 2.7.4.9) is a member of the NMP kinase family and catalyzes the phosphoryl transfer from the preferred phosphoryl donor, ATP, to thymidine monophosphate (TMP), yielding thymidine diphosphate (TDP). The TMK reaction is positioned at the junction of the de novo and salvage pathway of thymidine triphosphate (dTTP) synthesis, with TMK being the last specific enzyme for dTTP synthesis.
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