EC Number |
Natural Substrates |
---|
2.7.11.16 | ATP + G protein-coupled receptor |
phosphorylation has a regulatory role |
2.7.11.16 | ATP + G protein-coupled receptor |
regulation mechanism of GRK5, overview, regulation by phosphorylation at specific sites via distinct specific kinases, overview |
2.7.11.16 | ATP + G-protein-coupled receptor |
leading to receptor endocytosis |
2.7.11.16 | ATP + moesin |
phosphorylation at Thr66 |
2.7.11.16 | ATP + protein p105 |
- |
2.7.11.16 | ATP + rhodopsin |
- |
2.7.11.16 | ATP + [alpha-synuclein] |
the enzyme phosphorylates alpha-synuclein at Ser129 |
2.7.11.16 | ATP + [beta2-adrenergic receptor] |
GRK5 plays a distinctive role in the phosphorylation of the beta2AR |
2.7.11.16 | ATP + [dopamine D1 receptor] |
GRK4 constitutively phosphorylates active and inactive receptor, in the latter case diminishing stimulation of the receptor by dopamine, phosphorylation reduces receptor desensitization and internalization, followed by reduced cAMP accumulation |
2.7.11.16 | ATP + [G protein-coupled receptor] |
- |