EC Number   |
Natural Substrates |
|---|
    1.1.1.284 | formaldehyde + glutathione + NAD+ |
the synthesis of the enzyme is induced by methanol and repressed by glucose |
| 1.1.1.284 | formaldehyde + glutathione + NAD+ |
enzyme of methanol dissimilation. When cells are grown on glucose, the enzyme is not detected during the exponential growth, but is formed in the late stationary phase without addition of methanol. Enzyme is synthesized during growth on sorbitol, glycerol, ribose and xylose |
| 1.1.1.284 | formaldehyde + glutathione + NAD+ |
key step of the methanol catabolism in yeast |
| 1.1.1.284 | formaldehyde + glutathione + NAD+ |
resistance to formaldehyde is attributed to detoxification by oxidation |
| 1.1.1.284 | formaldehyde + glutathione + NAD+ |
enzyme of the formaldehyde oxidation pathway via the linear sequence |
| 1.1.1.284 | formaldehyde + glutathione + NAD+ |
enzyme is not essential but enhances the resistance against formaldehyde |
| 1.1.1.284 | formaldehyde + glutathione + NAD+ |
key enzyme in formaldehyde metabolism in microorganisms |
| 1.1.1.284 | formaldehyde + glutathione + NAD+ |
the enzyme activity in increased in livers from cancer patients independent of alcohol drinking or nondrinking, with no significant differences between primary and metastatic tumors |
| 1.1.1.284 | formaldehyde + glutathione + NAD+ |
the true substrate is S-hydroxymethylglutathione, spontaneously formed from formaldehyde and glutathione |
| 1.1.1.284 | formaldehyde + NAD+ + glutathione |
multifunctional enzyme, ADH3 constitutes a key enzyme in the detoxification of endogenous and exogenous formaldehyde, formaldehyde is released during intracellular metabolism of endogenous compounds or xenobiotics, expression of ADH3 might thus fulfill a protective role against DNA damage resulting from formaldehyde sources, ADH3 itself catalyzes oxidative reactions which produce NADH, most importantly the oxidation of formaldehyde |
