EC Number   |
Metals/Ions |
Reference |
|---|
    4.3.1.18 | Mn2+ |
the addition of Mn2+ induces a maximal recovery of 20% of the original activity in the EDTA-treated enzyme |
715627 |
| 4.3.1.18 | more |
no activation of the EDTA-treated enzyme is obtained after the addition of other divalent cations such as Mg2+, Ca2+, Cu2+ and Ni2+ |
715627 |
| 4.3.1.18 | Zn2+ |
- |
678079 |
| 4.3.1.18 | Zn2+ |
dependent on |
748453 |
| 4.3.1.18 | Zn2+ |
required |
728925, 729705, 729953, 730889 |
| 4.3.1.18 | Zn2+ |
the enzyme activity on D-serine decreases 20fold by EDTA treatment and recovers nearly completely by the addition of Zn2+. The hydroxyl group of D-serine directly coordinates the zinc ion, and the epsilon-NH2 group of Lys45 is a short distance from the substrate C-atom. The alpha-proton abstraction from D-serine by Lys45 and the elimination of the hydroxyl group seem to occur with the assistance of the zinc ion, resulting in the strict reaction specificity |
715627 |
