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Results 1 - 10 of 10
EC Number Metals/Ions Commentary Reference
Show all pathways known for 3.5.4.29Display the reaction diagram Show all sequences 3.5.4.29Ca2+ calcium is detected up to 10fold in molar excess of the protein. Treatment of the protein with Chelex (Na+ form) reduces the Ca2+ to 4fold excess but does not eliminate it 726948
Show all pathways known for 3.5.4.29Display the reaction diagram Show all sequences 3.5.4.29CoCl2 45% of Mg2+ diphosphate phosphohydrolase activation 639020
Show all pathways known for 3.5.4.29Display the reaction diagram Show all sequences 3.5.4.29K+ activates 726948
Show all pathways known for 3.5.4.29Display the reaction diagram Show all sequences 3.5.4.29K+ activation of GTP cyclohydrolase activity 639020
Show all pathways known for 3.5.4.29Display the reaction diagram Show all sequences 3.5.4.29Mg2+ required 726948
Show all pathways known for 3.5.4.29Display the reaction diagram Show all sequences 3.5.4.29Mg2+ required for cyclohydrolase activity, maximal activity at 4 mM, no other metal supports full activity, maximal diphosphate phosphohydrolase activity in the presence of 5 mM MgCl2 639020
Show all pathways known for 3.5.4.29Display the reaction diagram Show all sequences 3.5.4.29Mn2+ 7% of Mg2+ activation, 8% of Mg2+ diphosphate phosphohydrolase activation 639020
Show all pathways known for 3.5.4.29Display the reaction diagram Show all sequences 3.5.4.29more three metal ions are located in the active site, two of which occupy positions that are analogous to those occupied by divalent metal ions in the structures of a number of palm domain containing proteins, such as DNA polymerase I. Two conserved Asp residues that coordinate the metal ions, which are also found in palm domain containing proteins, are observed in GCH III. Site-directed variants (Asp->Asn) of these residues in GCH III are less active than wild-type. The third metal ion, most likely a potassium ion, is involved in substrate recognition through coordination of O6 of GTP. The arrangement of the metal ions in the active site suggests that GCH III utilizes two metal ion catalysis 726948
Show all pathways known for 3.5.4.29Display the reaction diagram Show all sequences 3.5.4.29NH4+ activates 726948
Show all pathways known for 3.5.4.29Display the reaction diagram Show all sequences 3.5.4.29Zn(OAc)2 21% of Mg2+ diphosphate phosphohydrolase activation 639020
Results 1 - 10 of 10