EC Number |
Metals/Ions |
Reference |
---|
3.4.22.54 | Ca2+ |
- |
649012 |
3.4.22.54 | Ca2+ |
activated by Ca2+ |
731896 |
3.4.22.54 | Ca2+ |
activates |
754170 |
3.4.22.54 | Ca2+ |
at less than 50 nM Ca2+ calpain-3 remains nonactivated, at 200 nM Ca2+ calpain-3 becomes active |
698991 |
3.4.22.54 | Ca2+ |
autolysis of skeletal muscle-specific calpain does not require Ca2+, calpastatinolysis occurs in a Ca2+-dependent manner |
665528 |
3.4.22.54 | Ca2+ |
Ca2+-regulated enzyme |
752852 |
3.4.22.54 | Ca2+ |
calcium-dependent protease |
670856 |
3.4.22.54 | Ca2+ |
calpain 3 is a calcium-dependent cysteine protease |
709092 |
3.4.22.54 | Ca2+ |
calpain 3/p94 is activated by Ca2+ and undergoes very rapid autolytic degradation even in the absence of Ca2+ |
709121 |
3.4.22.54 | Ca2+ |
calpain-3 autolyzes (becoming proteolytically active) in a tightly calcium-dependent manner. It remains in its nonactivated full-length form if [Ca2+] is maintained at up to 50 nM, the normal resting level, even with brief increases to 0.002-0.02 mM during repeated tetanic contractions, but it becomes active (though still bound) if [Ca2+] is kept slightly elevated at 200 nM (about 20% autolysis in 1 h). Calpain-3 does not spontaneously autolyze even when free in solution with 200 nM Ca2+ for up to 60 min |
698991 |