EC Number   |
Metals/Ions |
Reference |
|---|
   3.1.8.2 | Ca2+ |
dependent on |
694919, 701555, 713615, 749628, 752102 |
| 3.1.8.2 | Ca2+ |
dependent on, PTE Ca2+ binding structure comparisons |
751626 |
| 3.1.8.2 | Ca2+ |
required for activity, the wild type enzyme contains two Ca2+ ions |
703171 |
| 3.1.8.2 | Ca2+ |
required, Ca2+ ion in active site, coordinated to the moiety of DFP, two glutamines (Asn120 and Asn175), two negatively charged residues (Asp229 and Glu21), and two water molecules, thus completes its hepta-coordinated. Therefore, the metal ion plays an essential role in the precise orientation and activation of the substrate. The active site solvent molecule coordinating the catalytic calcium ion is identified as a water molecule other than a hydroxide |
752291, 755573 |
| 3.1.8.2 | Ca2+ |
required, metal center ligation of DFPase, structure overview |
750923 |
| 3.1.8.2 | Cd2+ |
activates |
713896, 714729 |
| 3.1.8.2 | Cd2+ |
slightly activates the hydrolysis of diisopropyl phosphofluoridate |
664937 |
| 3.1.8.2 | Co2+ |
activates |
713896, 749614 |
| 3.1.8.2 | Co2+ |
fully activates the hydrolysis of diisopropyl phosphofluoridate |
664937 |
| 3.1.8.2 | Mg2+ |
fully activates the hydrolysis of diisopropyl phosphofluoridate |
664937 |
