EC Number   |
Metals/Ions |
Reference |
|---|
   3.1.13.2 | Co2+ |
10 mM Co2+ supports catalytic activity |
729704 |
| 3.1.13.2 | K+ |
- |
671783, 677282 |
| 3.1.13.2 | K+ |
optimal concentration of 100-150 mM |
729704 |
| 3.1.13.2 | KCl |
activates |
664079 |
| 3.1.13.2 | Mg2+ |
- |
656665, 663833, 664051, 664053, 665679, 666034, 671783, 677282, 680758, 681520, 682980, 692325 |
| 3.1.13.2 | Mg2+ |
1-2 ions are required for RNase H and integrase activities of the reverse transcriptase, 2 different Mg2+ ions are required for polymerase activity and are loacted in the polymerase active site of the reverse transcriptase, 3,7-dihydroxytropolone inhibitors target the Mg2+ ions, overview |
663661 |
| 3.1.13.2 | Mg2+ |
a single ion is bound at the RNase H active site |
682980 |
| 3.1.13.2 | Mg2+ |
activates |
664079 |
| 3.1.13.2 | Mg2+ |
activates, causes conformational changes on some sites of the enzyme N-terminus near strand beta2 and beta3 and helix alphaA, residues 28-69 |
664048 |
| 3.1.13.2 | Mg2+ |
Asp358, Glu401 and Asp426 constitute the primary Mg2+ binding site of Ty3 RNase H domain |
652277 |
