EC Number   |
Metals/Ions |
Reference |
|---|
   2.7.1.137 | Ca2+ |
- |
691984 |
| 2.7.1.137 | Ca2+ |
CaCl2 stimulates enzyme forms PI3KI and PI3KII in absence of MnCl2. Half-maximal activation of PI3KI at 0.1 mM Ca2+, maximal activity at 1 mM, in presence of 10 mM MgCl2 further 2fold activation by 2 mM Ca2+. For PI3KII maximal activity is obtained in presence of 2 mM Ca2+, 1.6fold higher than that obtained in presence of 10 mM MgCl2 |
640848 |
| 2.7.1.137 | Ca2+ |
can use either MgATP2- or CaATP2- |
640862 |
| 2.7.1.137 | Ca2+ |
essential divalent cation in lipid kinase assays |
640861 |
| 2.7.1.137 | Ca2+ |
no effect at physiological concentrations |
640851 |
| 2.7.1.137 | Mg2+ |
- |
660643, 661328, 661498, 663296, 707454, 707877, 708336, 709003, 709207, 760521 |
| 2.7.1.137 | Mg2+ |
activation |
640848, 640850 |
| 2.7.1.137 | Mg2+ |
as MgATP2- |
661681 |
| 2.7.1.137 | Mg2+ |
can use either MgATP2- or CaATP2- |
640862 |
| 2.7.1.137 | Mg2+ |
dependent on, optimal at 5 mM |
660688 |
