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EC Number	Metals/Ions	Commentary	Reference
2.4.2.22	Co2+	efficiency is equal to Mn2+	638003
2.4.2.22	Co2+	less efficient in activation than Mn2+	638003
2.4.2.22	Mg2+	10 mM used in assay conditions	759629
2.4.2.22	Mg2+	dependent on	759072
2.4.2.22	Mg2+	magnesium and sulfate can bind together in the active site, in the absence of other products or substrates. The magnesium interacts with a highly conserved aspartate residue	638006
2.4.2.22	Mg2+	maximal catalytic activity with 0.06 mM	704046
2.4.2.22	Mg2+	required	758716, 759601
2.4.2.22	Mg2+	very low activation	638003
2.4.2.22	Mn2+	efficient activation	638003
2.4.2.22	Mn2+	maximal catalytic activity with 0.06 mM. Substitution of Mn2+ for Mg2+ results in ca. 2fold increase in the XPRT turnover rate without altering the xanthine Km value. Replacement of Mg2+ with Mn2+ increases the 5-phospho-alpha-D-ribose 1-diphosphate Km value ca. 2fold. XPRT-catalyzed hypoxanthine phosphoribosylation reveals that substitution of Mg2+ with Mn2+ results in a ca. 4fold increase in the hypoxanthine kcat value and ca. 3fold decrease in the hypoxanthine Km value	704046

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Release 2023.1 (January 2023)