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EC Number
Metals/Ions
Commentary
Reference
1.14.99.1
Fe2+
ferric heme enzyme
727083
1.14.99.1
Fe3+
-
671047
,
672192
1.14.99.1
Iron
each subunit contains a molecule of Fe3+-protoporphyrin IX noncovalently attached to the enzyme, the heme group is essential for both enzyme activities, the cofactor is released by induction of inhibitor nitroarachidonic acid
727873
1.14.99.1
Iron
possibly contains heme and non-heme iron
438374
1.14.99.1
Mn3+
substitution of ferric heme by MnIII protoporphyrin IX greatly diminishes the peroxidase activity, but has little effect on the cyclooxygenase activity
671047
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