EC Number |
Metals/Ions |
Reference |
---|
1.13.11.40 | Ca2+ |
Ca2+-regulated enzyme activity |
674505 |
1.13.11.40 | Ca2+ |
has three Ca2+ binding sites flanked by putative membrane insertion loops in the C2-like domain |
702338 |
1.13.11.40 | Fe2+ |
the catalytic iron in 8R-LOX is positioned by three invariant His384, His389, and His570 side chains and the terminal main chain. Fe2+ sits in the base of a large U-shaped cavity, positioned by invariant Leu385 on one side, and the iron and His384 and His389 on the other. Leu385 and the catalytic iron cradle the base of the U |
742865 |
1.13.11.40 | Iron |
during the hydrogen abstraction step, the hydroxyl group bound to the metal center activates the C-H bond of the double-allylic carbon center of the substrate that leads to the formation of a radical center at the substrate |
765268 |