EC Number   |
Metals/Ions |
Reference |
|---|
   1.1.3.9 | copper |
copper content: 1.2 mol of Cu per mol of wild-type enzyme, 0.96 mol of Cu per mol of mutant enzyme W290F, 1 mol Cu per mol of mutant enzyme W290G, 1.3 mol of Cu per mol of mutant enzyme W290H |
685149 |
| 1.1.3.9 | copper |
galactose oxidase is a copper-dependent enzyme that accomplishes 2e- substrate oxidation by pairing a single copper with an unusual cysteinylated tyrosine (Cys-Tyr) redox cofactor. The active site of GO contains only a single Cu . Post-translational biogenesis of Cys-Tyr is copper- and O2-dependent, resulting in a self-processing enzyme system. Cu(I) and Cu(II) enzyme states, Cu(I) active site modeling: on model uses the crystal structure of apo pre-processed GO (PDB ID 2VZ1) with Cu(I) manually added as the starting structure, while the other uses the crystal structure of processed Cu(II)-GO (PDB ID 1GOF) with the Cys-Tyr crosslink manually removed. In both cases, the model includes Cys228, Tyr272, Tyr495, His496 and His581 residues. Cu(I) activation mechanism, overview |
742748 |
| 1.1.3.9 | Cu2+ |
- |
389850, 389852, 389854, 389861, 389862, 389868, 389875, 389878, 696217, 699010 |
| 1.1.3.9 | Cu2+ |
0.4 mol copper per mol enzyme |
389851 |
| 1.1.3.9 | Cu2+ |
0.95 g-atom per 68000 g of protein |
389874, 389877 |
| 1.1.3.9 | Cu2+ |
1 atom copper per mol enzyme |
389873, 389881 |
| 1.1.3.9 | Cu2+ |
1.2 mol per mol enzyme |
389853 |
| 1.1.3.9 | Cu2+ |
a copper metalloenzyme, when fully reduced, the copper atom is at oxidation state +1 and can react with molecular oxygen to generate hydrogen peroxide |
743101 |
| 1.1.3.9 | Cu2+ |
a copper oxidase |
741991 |
| 1.1.3.9 | Cu2+ |
a copper-dependent enzyme |
743392 |
