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EC Number
Metals/Ions
Commentary
Reference
Ca2+
induction of the GTPase activity of brain tubulin, inhibition of tubulin assembly, prevents tubulin polymerization and induces rapid depolymerization of preformed microtubules
Co2+
stimulates, can partially substitute for Mg2+
Gd3+
stimulates the GTPase activity of brain tubulin, inhibits tubulin polymerization and induce microtubule depolymerization
K+
K+ ion at the GTP binding site allows the positioning of one water molecule that interacts with catalytic residues D235 and D238, K+ ion stabilizes dimer (molecular dynamics simulations)
Mg2+
required
Mg2+
required for activity, strong increase which reaches a plateau at 4 mM MgCl2
Mg2+
required, best metal cofactor, equirement of both Mg2+ and GTP for the polymerization of FtsZDr in higher ordered structure
Mn2+
stimulates slightly, can partially substitute for Mg2+
more
FtsZDr prefers Mg2+, followed by Co2+ for its GTPase activity. Mn2+ and Ni2+ support much lower GTPase activity, while GTP hydrolysis is nearly absent in the presence of Ca2+and Fe2+
Results 1 - 10 of 14 > >>