EC Number   |
Localization |
GeneOntology No. |
Reference |
|---|
   3.5.4.37 | cytoplasm |
full-length and N-terminally truncated forms of ADAR1 are simultaneously expressed in HeLa cells. Because the N-terminus of ADAR1 contains a nuclear export signal, the full-length protein (150000 Da) localizes predominantly in the cytoplasm, whereas the N-terminally truncated forms (110000 Da) are exclusively nuclear and accumulate in the nucleolus. In living cells, editing might be regulated by the intracellular compartmentalization of editing enzymes. ADAR1 shuttles between the nucleolus, the nucleoplasm and the cytoplasm |
GO:0005737 AmiGO QuickGO |
720090 |
| 3.5.4.37 | cytoplasm |
the ADAR1 p150 protein is found in both the cytoplasm and the nucleus, whereas the p110 protein localizes predominantly if not exclusively to the nucleus |
GO:0005737 AmiGO QuickGO |
721102 |
| 3.5.4.37 | cytosol |
two major isoforms of ADAR1, P150 and P110, named following their molecular weights, are yielded by different RNA splicings. The 150 kDa isoform, translated from exon 1a, is the full length protein that is mainly distributed in the cytosol. The 110 kDa isoform, coded by other alternative first exons and lacking the Z-DNA binding domains, is mainly located in the cell nucleus |
GO:0005829 AmiGO QuickGO |
718816 |
| 3.5.4.37 | nucleolus |
ADAR2 localizes exclusively to the nucleus and accumulates in the nucleolus. In living cells, editing might be regulated by the intracellular compartmentalization of editing enzymes. ADAR2 shuttles between the nucleolus and the nucleoplasm |
GO:0005730 AmiGO QuickGO |
720090 |
| 3.5.4.37 | nucleolus |
full-length and N-terminally truncated forms of ADAR1 are simultaneously expressed in HeLa cells. Because the N-terminus of ADAR1 contains a nuclear export signal, the full-length protein (150000 Da) localizes predominantly in the cytoplasm, whereas the N-terminally truncated forms (110000 Da) are exclusively nuclear and accumulate in the nucleolus. In living cells, editing might be regulated by the intracellular compartmentalization of editing enzymes. ADAR1 shuttles between the nucleolus, the nucleoplasm and the cytoplasm |
GO:0005730 AmiGO QuickGO |
720090 |
| 3.5.4.37 | nucleus |
- |
GO:0005634 AmiGO QuickGO |
720953 |
| 3.5.4.37 | nucleus |
nuclear extract |
GO:0005634 AmiGO QuickGO |
719813 |
| 3.5.4.37 | nucleus |
the ADAR1 p150 protein is found in both the cytoplasm and the nucleus, whereas the p110 protein localizes predominantly if not exclusively to the nucleus |
GO:0005634 AmiGO QuickGO |
721102 |
| 3.5.4.37 | nucleus |
two major isoforms of ADAR1, P150 and P110, named following their molecular weights, are yielded by different RNA splicings. The 150 kDa isoform, translated from exon 1a, is the full length protein that is mainly distributed in the cytosol. The 110 kDa isoform, coded by other alternative first exons and lacking the Z-DNA binding domains, is mainly located in the cell nucleus |
GO:0005634 AmiGO QuickGO |
718816 |
