EC Number |
Localization |
GeneOntology No. |
Reference |
---|
3.4.24.87 | cell surface |
- |
GO:0009986 AmiGO QuickGO |
713561 |
3.4.24.87 | cell surface |
ADAMTS13 binds to endothelial cells in a specific, reversible, and time-dependent manner with a Kd of 58 nM. Binding requires the COOH-terminal thrombospondin type 1 repeats of the protease. Binding is inhibited in the presence of heparin and by trypsin treatment of the cells |
GO:0009986 AmiGO QuickGO |
712393 |
3.4.24.87 | endoplasmic reticulum |
homogeneous distribution of wild-type ADAMTS13 in cis-Golgi and endoplasmic reticulum compartments. Reduction of ADAMTS13(Val88Met) in both compartments. ADAMTS13(Gly1239Val) fails to reach the cis-Golgi compartment and remains in the endoplasmic reticulum |
GO:0005783 AmiGO QuickGO |
668882 |
3.4.24.87 | extracellular |
- |
- |
710732, 710826, 710827, 711560, 711561, 711563, 711564, 711565, 711567, 711569, 711571, 711574, 711575, 711576, 711578, 711579, 711809, 712070, 712115, 712127, 712195, 712203, 712393, 712568, 712569, 712899, 712900, 712901, 713079, 713347, 713381, 713400, 713531, 713532, 713534, 713536, 713560, 713561 |
3.4.24.87 | extracellular |
ADAMTS-13 is released directly from the Golgi to the cell exterior without an organelle storage site, e.g. a cytoplasmic granule |
- |
711570 |
3.4.24.87 | extracellular |
plasma |
- |
650102, 650709, 650710, 650712, 650714, 650715, 650717, 650725, 651439, 652191, 652431, 652481, 653678 |
3.4.24.87 | extracellular |
secrete enzyme |
- |
713533 |
3.4.24.87 | extracellular |
secreted enzyme |
- |
711562, 713116 |
3.4.24.87 | extracellular |
the enzyme is secreted |
- |
712099, 713189 |
3.4.24.87 | Golgi apparatus |
homogeneous distribution of wild-type ADAMTS13 in cis-Golgi and endoplasmic reticulum compartments. Reduction of ADAMTS13(Val88Met) in both compartments. ADAMTS13(Gly1239Val) fails to reach the cis-Golgi compartment and remains in the endoplasmic reticulum |
GO:0005794 AmiGO QuickGO |
668882 |